mODa 9 – Advances in Model-Oriented Design and Analysis

Impact of Stratified Randomization in Clinical Trials.- The Non-Uniqueness of Some Designs for Discriminating Between Two Polynomial Models in One Variable.- Covariate Adjusted Designs for Combining Efficiency, Ethics and Randomness in Normal Response Trials.- Split-Plot and Robust Designs: Weighting and Optimization in the Multiple Response Case.- An Improvement in the Lack-of-Fit Optimality of the (Absolutely) Continuous Uniform Design in Respect of Exact Designs.- Optimal Allocation Proportion for a Two-Treatment Clinical Trial Having Correlated Binomial Responses.- Sample Size Determination for Multivariate Performance Analysis with Complex Designs.- Optimal Design for Compositional Data.- Dose Finding Experiments: Responses of Mixed Type.- Pharmacokinetic Studies Described by Stochastic Differential Equations: Optimal Design for Systems with Positive Trajectories.- On Testing Hypotheses in Response-Adaptive Designs Targeting the Best Treatment.- Towards Gaussian Process-based Optimization with Finite Time Horizon.- Optimal Designs for Linear Logistic Test Models.- A Class of Screening Designs Robust to Active Second-Order Effects.- D-Optimal Design for a Five-Parameter Logistic Model.- Sequential Barycentric Interpolation.- Some Considerations on the Fisher Information in Nonlinear Mixed Effects Models.- Designs with High Breakdown Point in Nonlinear Models.- A Note on the Relationship between Two Approaches to Optimal Design under Correlation.- The Role of the Nugget Term in the Gaussian Process Method.- A Bonferroni-Adjusted Trend Testing Method for Excess over Highest Single Agent.- Asymptotic Properties of Adaptive Penalized Optimal Designs over a Finite Space.- Filling and D-optimal Designs for the Correlated Generalized Exponential Model.- Designs for Dose Finding Studies on Safety and Efficacy.- A Radial Scanning Statistic for Selecting Space-filling Designs in Computer Experiments.- Optimal Designs for Two-Colour Microarray Experiments for Estimating Interactions.- Discrimination Between Random and Fixed Effect Logistic Regression Models.- Estimation and Optimal Designing under Latent Variable Models for Paired Comparisons Studies via a Multiplicative Algorithm.- Pointwise Consistency of the Kriging Predictor with Known Mean and Covariance Functions.- Information in a Two-stage Adaptive Optimal Design for Normal Random Variables having a One Parameter Exponential Mean Function.