QSAR in Environmental Toxicology

Foreword.- Structure—activity relationships for toxicity of hydrocarbons, chlorinated hydrocarbons and oils to Daphnia magna.- Comparative toxicity and metabolism of tetrachlorobenzene isomers.- An examination of the role of rotational barriers in the toxicology of PCB’s.- The use of rapid biochemical indicators of toxicant stress to generate biological data bases for QSAR.- The use of SIMCA pattern recognition in the analysis of complex chromatographic data.- Structure—activity models of biological oxygen demand.- Environmental hazard profile—test results as related to structures and translation into the environment.- Predicting the environmental fate of toxic contaminants in large lakes: data requirements for mathematical models.- The need and requirements for quantitative structure—activity relations (QSAR) in the Great Lakes Water Quality Program.- Assessment of mutagenic effects in amphibian embryos.- Lethal dose versus lethal concentration as indicator of contaminant toxicity to fish.- QSAR studies on chlorophenols, chlorobenzenes and para—substituted phenols.- Quantitative structure—activity relationships in ecotoxicology: possibilities and limits.- Toxicities of selected chloroanilines to four strains of yeast.- Comparative structure—toxicity relationships between acute and chronic effects to aquatic organisms.- Relationships between physical—chemical and environmental partitioning coefficients.- Validation of fish toxicity QSARs for certain non-reactive, non—electrolyte organic compounds.- The relationship between bioconcentration factor in rainbow trout and physical—chemical properties for some halogenated compounds.- Toxicities of chloroanilines to Photobacterium phosphoreum and their correlations with effects on other organisms and structural parameters.- Structure—activity correlations of selected azaarenes, aromatic amines, and nitroaromatics.- Data evaluation in the development of QSAR.- General Discussion.- Author Index.- Formula Index.