Midkine: From Embryogenesis to Pathogenesis and Therapy
Paperback Engels 2014 2012e druk 9789400799486Samenvatting
Carl Edward Sagan’s (1934-1996) one of the famous quotation was “Who are we? We find that we live on an insignificant planet of a humdrum star lost in a galaxy tucked away in some forgotten corner of a universe in which there are far more galaxies than people.“ From past to date, well-known molecules, enzymes, proteins, lipids and carbohydrates are studied in the pathogenesis of several diseases both as a diagnostic/prognostic biomarker and therapeutic agent. The underlying mechanism of unexplained diseases and failure of therapies are frequently studied with well-known biomarkers, but remain unclear in many cases. As Dr. Sagan said other keys are still waiting to be known in some forgotten corner of a body universe, we find strength to propose that one of them can be the growth factor with cytokine activity named “Midkine” This book summarizes the extensive up-to-date literature overeview with the lastest work of experts about midkine in a detailed format that conveys its role as both a pathologic factor and therapeutic agent.
Specificaties
Lezersrecensies
Inhoudsopgave
CHAPTER 1 General information on midkine
CHAPTER 2 The role of midkine in neural development and patterning
CHAPTER 3 Midkine- A player in innate immunity
CHAPTER 4 Midkine/p63 axis in regulation of epithelial-mesenchymal transition
CHAPTER 5 Immunochemical methods for the detection of midkine in samples of human origin
CHAPTER 6 Circulating midkine in malignant, inflammatory, and infectious diseases: a systematic review
PART II: MIDKINE AND INFLAMMATION
CHAPTER 7 Midkine in inflammation and inflammatory diseases
CHAPTER 8 Rheumatoid arthritis and midkine
PART III: MIDKINE AND THE CARDIOVASCULAR SYSTEM
CHAPTER 9 Midkine and heart failure
CHAPTER 10 Vascular restenosis and midkine
CHAPTER 11 The potential of MK through the renin-angiotensin system
PART IV: MIDKINE AND THE NERVOUS SYSTEM
CHAPTER 12 Midkine and Multiple sclerosis
CHAPTER 13 MK gene transfer in brain infarction
CHAPTER 14 Midkine in psychiatric and neurodegenerative diseases
PART V: MIDKINE AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGING
CHAPTER 15 Role of midkine in nephrogenesis and kidney Disease
CHAPTER 16 Midkine, a factor promoting cytoplasmic maturation of oocytes
CHAPTER 17 Endometriosis may be promoted by midkine: possible involvement of ovarian follicles
CHAPTER 18 Stem cells and midkine
CHAPTER 19 Midkine in skeletal physiology
PART VI MIDKINE AND CANCER
CHAPTER 20 Midkine and chemotherapy resistance in cancers
CHAPTER 21 A gene medicine with the midkine transcriptional regulation as new cancer therapeutics
CHAPTER 22 Midkine as a tumor shared antigen
CHAPTER 23 Midkine in prostate cancer
CHAPTER 24 Midkine is a potential therapeutic target of hepatocellular carcinoma
CHAPTER 25 Midkine in glioblastoma with the modulator role switching autophagy to cell death or cell survival
CHAPTER 26 Colon cancer and midkine
CHAPTER 27 Osteosarcoma and midkine
Index.
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