Tobacco Smoking Addiction: Epidemiology, Genetics, Mechanisms, and Treatment

<p>The Prevalence of Smoking and Its Associated Diseases.- Addiction Genetics: Basic Concepts and Techniques.- Estimation of Genetic and Environmental Contributions to Smoking Addiction.- Identified Susceptibility Loci for Nicotine Addiction Based on Genome-Wide Linkage Analyses.- Involvement of Variants in Gene Clusters CHRNA5/A3/B4 on Chromosome 15 to Smoking Behaviors and Lung Cancer.- Contribution of Variants in CHRNB3/A6 Gene Cluster on Chromosome 8 to Smoking Dependence.- Genetic Contribution of Variants in GABAergic Signaling to Nicotine Dependence.- Contribution of Variants in DRD2/ANKK1 on Chromosome 11 with Smoking and Other Addictions.- Significant Contribution of Variants in Serotonin Transporter and Receptor Genes to Smoking Dependence.- Converging Findings from Linkage and Association Analyses on Susceptibility Genes for Smoking Addiction.- Contribution of Gene–Gene and Gene–Environmental Interactions to Tobacco Smoking.- Identification of BiologicalPathways Associated with Smoking Initiation/Progression, Nicotine Dependence, and Smoking Cessation.- Neuroproteomics and Its Applications in Research on Nicotine and Other Drugs of Abuse.- Regulatory Roles of MicroRNAs in Addictions and Other Psychiatric Diseases.- Tobacco Smoking, Food Intake, and Weight Control.- Nicotine Modulates Innate Immune Pathways via α7 Nicotinic Acetylcholine Receptor.- DNA Methylation Analysis Reveals a Strong Connection between Tobacco Smoking and Cancer Pathogenesis.- Evolutionary Relations of Genes Encoding Nicotinic Acetylcholine Receptor Subunits.- Management, Pharmacotherapies, and Precision Medicine for Smoking Cessation.- Background and Biology of and Health Concerns about Electronic Cigarettes.- Grand Challenges and Opportunities for Psychiatry, Including Nicotine Addiction Research.</p>