Proteostasis

Investigating Molecular Dynamics in Neurodegenerative Disorders

Paperback Engels 2026 9789819662043
€ 276,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Samenvatting

This book explores the role of proteostasis in neurodegenerative disorders, focusing on protein homeostasis in long-lived, nondividing cells like neurons. It examines how disruptions in proteostasis, influenced by factors such as oxidative stress, aging, and environmental stress, contribute to diseases like Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis. The book begins with an overview of the epidemiology and management of neurodegenerative diseases. Subsequent chapters delve into the mechanisms governing proteostasis, highlighting the ubiquitin-proteasome system, molecular chaperones, and co-chaperones in protein folding and degradation. It further explores how impairments in these pathways contribute to neuroinflammation and disease progression. By providing insights into these cellular processes, the book aims to enhance understanding and support the development of potential therapeutic strategies.

Specificaties

ISBN13:9789819662043
Taal:Engels
Bindwijze:Paperback
Aantal pagina's:429
Uitgever:Springer Nature Singapore

Lezersrecensies

Wees de eerste die een lezersrecensie schrijft!

Inhoudsopgave

1. Neurodegenerative disorder: An overview.- 2. Alzheimer's: Epidemiology, pathophysiology, diagnosis and treatments.- 3. Parkinson’s Disease: Epidemiology, Pathophysiology, Diagnosis, and Treatment.- 4. A Proteasome System and Impairment in Ubiquitin-Proteasome System in Neurodegeneration and Neuroprotection.- 5. Protein misfolding and cell death in neurodegenerative diseases: consequences and strategies.- 6. Proteostasis disturbances and inflammation in neurodegenerative diseases.- 7. Proteostasis: Investigating Molecular Dynamics in Neurodegenerative Disorders.- 8. Biomarkers for Proteostasis Disruption: An Overview.- 9. Insights into Proteostasis System in Ageing and Neurodegenerative Disorders.- 10. The role of chaperones and cochaperones in synaptic proteostasis and neurodegenerative disease.- 11. Proteasomal Degradation and Autophagy in Neurodegenerative Diseases.- 12. The Insight into the Role of Protein Misfolding and Tau Oligomers in Alzheimer's Disease.- 13. Therapeutic Strategies Targeting Amyloid-β in Alzheimer’s Disease.- 14. A comprehensive review of the ubiquitin-proteasome system in synapse remodeling and neurodegenerative diseases.- 15. Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases.- 16. Ameliorative Effects of Heat Shock Proteins in Therapeutic Implications of Neurodegenerative Diseases.- 17. Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.- 18. Future Perspectives and Challenges in the Field of Proteostasis and Neurodegenerative Disorders.

Managementboek Top 100

€ 276,99
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Rubrieken

    Personen

      Trefwoorden

        Artikelen

          Proteostasis